Publications

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A scaleable inducible knockout system for studying essential gene function in the malaria parasite

Abhinay Ramaprasad, Michael J Blackman

Cold Spring Harbor Laboratory  ·  15 Jan 2024  ·  doi:10.1101/2024.01.14.575607

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2024

Single-step assembly of double guide plasmid (pCas9-Duo) for gene-editing in Plasmodium v1

Abhinay Ramaprasad

ZappyLab, Inc.  ·  11 Jun 2024  ·  doi:10.17504/protocols.io.n2bvjn9d5gk5/v1

A scaleable inducible knockout system for studying essential gene function in the malaria parasite

Abhinay Ramaprasad, Michael J Blackman

Cold Spring Harbor Laboratory  ·  15 Jan 2024  ·  doi:10.1101/2024.01.14.575607

2023

A patatin-like phospholipase is important for mitochondrial function in malaria parasites

Emma Pietsch, Abhinay Ramaprasad, Sabrina Bielfeld, Yvonne Wohlfarter, Bohumil Maco, …, Markus A. Keller, Dominique Soldati-Favre, Michael J. Blackman, Tim-Wolf Gilberger, Paul-Christian Burda

mBio  ·  19 Dec 2023  ·  doi:10.1128/mbio.01718-23

Global analysis of putative phospholipases in Plasmodium falciparum reveals an essential role of the phosphoinositide-specific phospholipase C in parasite maturation

Paul-Christian Burda, Abhinay Ramaprasad, Sabrina Bielfeld, Emma Pietsch, Anna Woitalla, …, Aaron Sait, Lucy M. Collinson, Dominik Schwudke, Michael J. Blackman, Tim-Wolf Gilberger

mBio  ·  25 Jul 2023  ·  doi:10.1128/mbio.01413-23

A malaria parasite phospholipase facilitates efficient asexual blood stage egress.

Abhinay Ramaprasad, Paul-Christian Burda, Konstantinos Koussis, James A Thomas, Emma Pietsch, …, Steven A Howell, James I MacRae, Ambrosius P Snijders, Tim-Wolf Gilberger, Michael J Blackman

PLoS pathogens  ·  23 Jun 2023  ·  pmid:37352369

2022

A choline-releasing glycerophosphodiesterase essential for phosphatidylcholine biosynthesis and blood stage development in the malaria parasite

Abhinay Ramaprasad, Paul-Christian Burda, Enrica Calvani, Aaron J Sait, Susana Alejandra Palma-Duran, …, Fiona Hackett, James Macrae, Lucy Collinson, Tim Wolf Gilberger, Michael J Blackman

eLife  ·  28 Dec 2022  ·  doi:10.7554/eLife.82207

Pangenome Analysis of the Soilborne Fungal Phytopathogen

Abhinav Kaushik, Daniel P Roberts, Abhinay Ramaprasad, Sara Mfarrej, Mridul Nair, Dilip K Lakshman, Arnab Pain

Frontiers in microbiology  ·  25 Mar 2022  ·  pmid:35401459

2021

Estimating the effectiveness of routine asymptomatic PCR testing at different frequencies for the detection of SARS-CoV-2 infections.

Joel Hellewell, Timothy W Russell, Rupert Beale, Gavin Kelly, Catherine Houlihan, Eleni Nastouli, Adam J Kucharski

BMC medicine  ·  27 Apr 2021  ·  pmid:33902581

Plasmodium vinckei genomes provide insights into the pan-genome and evolution of rodent malaria parasites

Abhinay Ramaprasad, Severina Klaus, Olga Douvropoulou, Richard Culleton, Arnab Pain

BMC Biology  ·  23 Apr 2021  ·  doi:10.1186/s12915-021-00995-5

2020

Open collaborative writing with Manubot

Daniel S. Himmelstein, Vincent Rubinetti, David R. Slochower, Dongbo Hu, Venkat S. Malladi, Casey S. Greene, Anthony Gitter

PLOS Computational Biology  ·  04 Dec 2020  ·  doi:10.1371/journal.pcbi.1007128

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MRE11 Is Crucial for Malaria Parasite Transmission and Its Absence Affects Expression of Interconnected Networks of Key Genes Essential for Life

David S. Guttery, Abhinay Ramaprasad, David J. P. Ferguson, Mohammad Zeeshan, Rajan Pandey, Declan Brady, Anthony A. Holder, Arnab Pain, Rita Tewari

Cells  ·  03 Dec 2020  ·  doi:10.3390/cells9122590

Clinical outcomes of COVID-19 in long-term care facilities for people with epilepsy.

Simona Balestrini, Matthias J Koepp, Sonia Gandhi, Hannah M Rickman, Gee Yen Shin, …, Rosemarie Pardington, Eleni Nastouli, Charles Swanton, Josemir W Sander, Sanjay M Sisodiya

Epilepsy & behavior : E&B  ·  05 Nov 2020  ·  pmid:33279440

Plasmodium vinckei genomes provide insights into the pan-genome and evolution of rodent malaria parasites

Abhinay Ramaprasad, Severina Klaus, Olga Douvropoulou, Richard Culleton, Arnab Pain

Cold Spring Harbor Laboratory  ·  07 Sep 2020  ·  doi:10.1101/2020.09.07.286369

Scalable and robust SARS-CoV-2 testing in an academic center.

Jim Aitken, Karen Ambrose, Sam Barrell, Rupert Beale, Ganka Bineva-Todd, …, Philip A Walker, Sophia Ward, Wai Keong Wong, Joshua Wright, Mary Wu

Nature biotechnology  ·  01 Aug 2020  ·  pmid:32555528

Pandemic peak SARS-CoV-2 infection and seroconversion rates in London frontline health-care workers.

Catherine F Houlihan, Nina Vora, Thomas Byrne, Dan Lewer, Gavin Kelly, …, George Kassiotis, Laura E McCoy, Charles Swanton, Andrew Hayward, Eleni Nastouli

Lancet (London, England)  ·  09 Jul 2020  ·  pmid:32653078

Malaria parasites regulate intra-erythrocytic development duration via serpentine receptor 10 to coordinate with host rhythms

Amit K. Subudhi, Aidan J. O’Donnell, Abhinay Ramaprasad, Hussein M. Abkallo, Abhinav Kaushik, …, Fathia Ben Rached, Osamu Kaneko, Richard Culleton, Sarah E. Reece, Arnab Pain

Nature Communications  ·  02 Jun 2020  ·  doi:10.1038/s41467-020-16593-y

Constructing knowledge graphs and their biomedical applications

David N. Nicholson, Casey S. Greene

Computational and Structural Biotechnology Journal  ·  01 Jan 2020  ·  doi:10.1016/j.csbj.2020.05.017

2019

Whole genome sequencing of amplified Plasmodium knowlesi DNA from unprocessed blood reveals genetic exchange events between Malaysian Peninsular and Borneo subpopulations

Ernest Diez Benavente, Ana Rita Gomes, Jeremy Ryan De Silva, Matthew Grigg, Harriet Walker, …, Sarah Auburn, Lau Yee Ling, Nicholas M. Anstey, Taane G. Clark, Susana Campino

Scientific Reports  ·  08 Jul 2019  ·  doi:10.1038/s41598-019-46398-z

2018

Proteomic profiling of the plasma of Gambian children with cerebral malaria

Ehab M. Moussa, Honglei Huang, Marie L. Thézénas, Roman Fischer, Abhinay Ramaprasad, …, Muminatou Jallow, Arnab Pain, Dominic Kwiatkowski, Benedikt M. Kessler, Climent Casals-Pascual

Malaria Journal  ·  24 Sep 2018  ·  doi:10.1186/s12936-018-2487-y

A fast and cost-effective microsampling protocol incorporating reduced animal usage for time-series transcriptomics in rodent malaria parasites

Abhinay Ramaprasad, Amit Kumar Subudhi, Richard Culleton, Arnab Pain

Cold Spring Harbor Laboratory  ·  20 Jun 2018  ·  doi:10.1101/350546

Sci-Hub provides access to nearly all scholarly literature

Daniel S Himmelstein, Ariel Rodriguez Romero, Jacob G Levernier, Thomas Anthony Munro, Stephen Reid McLaughlin, Bastian Greshake Tzovaras, Casey S Greene

eLife  ·  01 Mar 2018  ·  doi:10.7554/eLife.32822

Timing of host feeding drives rhythms in parasite replication

Kimberley F. Prior, Daan R. van der Veen, Aidan J. O’Donnell, Katherine Cumnock, David Schneider, …, Amit Subudhi, Abhinay Ramaprasad, Samuel S. C. Rund, Nicholas J. Savill, Sarah E. Reece

PLOS Pathogens  ·  26 Feb 2018  ·  doi:10.1371/journal.ppat.1006900

2017

Rapid identification of genes controlling virulence and immunity in malaria parasites

Hussein M. Abkallo, Axel Martinelli, Megumi Inoue, Abhinay Ramaprasad, Phonepadith Xangsayarath, …, Osamu Kaneko, Ville Mustonen, Christopher J. R. Illingworth, Arnab Pain, Richard Culleton

PLOS Pathogens  ·  12 Jul 2017  ·  doi:10.1371/journal.ppat.1006447

Emergence of Indigenous Artemisinin-Resistant Plasmodium falciparum in Africa.

Feng Lu, Richard Culleton, Meihua Zhang, Abhinay Ramaprasad, Lorenz von Seidlein, …, Didier Menard, Arnab Pain, Haitao Yang, Qingfeng Zhang, Jun Cao

The New England journal of medicine  ·  22 Feb 2017  ·  pmid:28225668

2016

Genome-scale comparison of expanded gene families in Plasmodium ovale wallikeri and Plasmodium ovale curtisi with Plasmodium malariae and with other Plasmodium species

Hifzur Rahman Ansari, Thomas J. Templeton, Amit Kumar Subudhi, Abhinay Ramaprasad, Jianxia Tang, …, Colin J. Sutherland, John W. Barnwell, Richard Culleton, Jun Cao, Arnab Pain

International Journal for Parasitology  ·  01 Oct 2016  ·  doi:10.1016/j.ijpara.2016.05.009

Normocyte-binding protein required for human erythrocyte invasion by the zoonotic malaria parasite Plasmodium knowlesi

Robert W. Moon, Hazem Sharaf, Claire H. Hastings, Yung Shwen Ho, Mridul B. Nair, …, Neil Almond, Yee Ling Lau, Arnab Pain, Michael J. Blackman, Anthony A. Holder

Proceedings of the National Academy of Sciences  ·  14 Jun 2016  ·  doi:10.1073/pnas.1522469113

2015

Plasmodium P-Type Cyclin CYC3 Modulates Endomitotic Growth during Oocyst Development in Mosquitoes

Magali Roques, Richard J. Wall, Alexander P. Douglass, Abhinay Ramaprasad, David J. P. Ferguson, …, Hiroyuki Yamano, Anthony A. Holder, Arnab Pain, Bill Wickstead, Rita Tewari

PLOS Pathogens  ·  13 Nov 2015  ·  doi:10.1371/journal.ppat.1005273

Chromerid genomes reveal the evolutionary path from photosynthetic algae to obligate intracellular parasites

Yong H Woo, Hifzur Ansari, Thomas D Otto, Christen M Klinger, Martin Kolisko, …, Thomas J Templeton, Ross F Waller, Julius Lukeš, Miroslav Oborník, Arnab Pain

eLife  ·  15 Jul 2015  ·  doi:10.7554/eLife.06974

Endosymbiosis undone by stepwise elimination of the plastid in a parasitic dinoflagellate

Sebastian G. Gornik, Febrimarsa, Andrew M. Cassin, James I. MacRae, Abhinay Ramaprasad, …, Malcolm J. McConville, Antony Bacic, Geoffrey I. McFadden, Arnab Pain, Ross F. Waller

Proceedings of the National Academy of Sciences  ·  20 Apr 2015  ·  doi:10.1073/pnas.1423400112

Comprehensive Evaluation of Toxoplasma gondii VEG and Neospora caninum LIV Genomes with Tachyzoite Stage Transcriptome and Proteome Defines Novel Transcript Features

Abhinay Ramaprasad, Tobias Mourier, Raeece Naeem, Tareq B. Malas, Ehab Moussa, Aswini Panigrahi, Sarah J. Vermont, Thomas D. Otto, Jonathan Wastling, Arnab Pain

PLOS ONE  ·  13 Apr 2015  ·  doi:10.1371/journal.pone.0124473

2014

Genome-wide Functional Analysis of Plasmodium Protein Phosphatases Reveals Key Regulators of Parasite Development and Differentiation

David S. Guttery, Benoit Poulin, Abhinay Ramaprasad, Richard J. Wall, David J.P. Ferguson, …, Edward W. Tate, Anthony A. Holder, Bill Wickstead, Arnab Pain, Rita Tewari

Cell Host & Microbe  ·  01 Jul 2014  ·  doi:10.1016/j.chom.2014.05.020

The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction

A. P. Jackson, T. D. Otto, A. Darby, A. Ramaprasad, D. Xia, …, B. Shiels, A. Tait, M. Berriman, D. R. Allred, A. Pain

Nucleic Acids Research  ·  05 May 2014  ·  doi:10.1093/nar/gku322

Interleukin-10 Regulates Hepcidin in Plasmodium falciparum Malaria

Honglei Huang, Abigail A. Lamikanra, Matthew S. Alkaitis, Marie L. Thézénas, Abhinay Ramaprasad, Ehab Moussa, David J. Roberts, Climent Casals-Pascual

PLoS ONE  ·  10 Feb 2014  ·  doi:10.1371/journal.pone.0088408

2013

PfHPRT: A New Biomarker Candidate of Acute Plasmodium falciparum Infection

Marie L. Thézénas, Honglei Huang, Madi Njie, Abhinay Ramaprasad, Davis C. Nwakanma, …, Katalin Digleria, Michael Walther, David J. Conway, Benedikt M. Kessler, Climent Casals-Pascual

Journal of Proteome Research  ·  12 Feb 2013  ·  doi:10.1021/pr300858g

2012

Defining the protein interaction network of human malaria parasite Plasmodium falciparum

Abhinay Ramaprasad, Arnab Pain, Timothy Ravasi

Genomics  ·  01 Feb 2012  ·  doi:10.1016/j.ygeno.2011.11.006

Studying Different Clinical Syndromes Of Paediatric Severe Malaria Using Plasma Proteomics

Abhinay Ramaprasad

KAUST Research Repository  ·  01 Jan 2012  ·  doi:10.25781/KAUST-1XW71

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[no publisher info]  ·  [no date info]  ·  handle:10754/626109